
Polynucleotides are the science behind Rejuran, but what exactly are they and how do they benefit the skin? This accessible guide explains polynucleotides (PN) and why they matter for skin quality.
What Are Polynucleotides?
Polynucleotides are chains of nucleotides, the building blocks of DNA. In treatments like Rejuran, they are purified from salmon DNA and valued for their compatibility with human skin. See Rejuran ingredients explained.
How They Support the Skin
- Strong water-binding for hydration
- Skin-conditioning properties
- Supporting the skin environment associated with healthy renewal

Why Salmon DNA?
Salmon DNA fragments are highly compatible with human skin, which is why they are used in polynucleotide treatments. For a deeper dive, read collagen and skin regeneration. A peer-reviewed overview is available via the National Library of Medicine.
Frequently Asked Questions
Are polynucleotides the same as PDRN?
They are closely related terms. Both refer to DNA-derived compounds valued for skin benefits.
Are polynucleotides safe?
They are widely used and generally well tolerated, but a practitioner assessment is always recommended.
Final Thoughts
Polynucleotides are the heart of Rejuran, prized for hydration and skin conditioning. Understanding them helps explain why Rejuran has become such a trusted skin-quality treatment.
This article is for general informational purposes only and is not medical advice; consult a qualified practitioner for guidance specific to your skin.
